NIH+DOE request for information for advancing high resolution bioimaging technologies

By achan
April 24, 2020

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Dear Lightsource User:

The LCLS at SLAC National Accelerator Laboratory is reaching out to the biological research community in the context of an NIH-DOE request for information (RFI) on “strategies to advance the utility of high resolution bioimaging technologies that already exist and that need to be created.

Current instruments at LCLS provide unique capabilities for characterizing biological samples at high spatial and temporal resolution allowing key insight into structural features or to reveal macromolecular dynamics and energy landscapes at ambient temperatures. We wish to address how to further your research using the unique capabilities offered by LCLS.

In the context of the RFI, we would appreciate answers to a few specific questions:

  • What biological research in your area of expertise could be advanced with LCLS and could drive priorities for new Capabilities?
  • What are the current gaps and/or challenges with LCLS instruments that limit their impact on your research or on the broader area of bioscience?
  • What scientific, methodological, engineering or operational barriers limit the use of LCLS by your team or your community?

or we encourage you to directly respond to the RFI itself.

Independently of the RFI, we would like to hear your suggestions, both to inform immediate term actions such as for the current call for coronavirus beamtime, and to inform priorities for longer term developments and targeted access to LCLS.

We will be happy to discuss this in detail with you or answer any questions related to this RFI and LCLS capabilities. Please contact Mark Hunter ( We look forward to having an active discussion with you about how your research can be enabled by LCLS.