LCLS Call for PCS Proposals for Run 21

By pjones
September 2, 2022

Call for PCS Proposals - Run 21
Linac Coherent Light Source - SLAC National Accelerator Laboratory

Deadline: 4:00 p.m. Pacific Daylight Time (PDT) 04 October 2022 (Submission deadline extended)
This call is for experiments to run from October 2022 through June 2023

We are pleased to announce the next call for LCLS Protein Crystal Screening (PCS) Proposals. LCLS is seeking proposals for PCS beamtime to be awarded during LCLS Run 21 expected to be scheduled between October 2022 and June 2023.

The LCLS Protein Crystal Screening (PCS) program aims to enable increased access to LCLS beamtime for biological structure determination by making use of short, 6-12 hour runs to screen the quality of different sample preparations or potentially collect a full data set under good running conditions. To enable measurements within such a short time frame and maximize efficiency and the chances of success, these studies must be carried out with limited instrumentation flexibility to minimize the time impact of setup changes.

PCS experiments at atmospheric pressure are expected to be available at the MFX instrument with multiple options likely to be available, including a fixed target system, a Droplet-on-Demand system, and a liquid jet system compatible with various types of jets.

The following sample delivery configurations (at the discretion of LCLS) are expected to be supported at MFX (in atmosphere) for PCS in this current call for proposals:

  • Gas Dynamic Virtual Nozzle (GDVN)
  • Dual Flow Focusing Nozzles (DFFN)
  • Lipidic Cubic Phase (LCP) jets
  • Microfluidic Electrokinetic Sample Holder (MESH)
  • Droplet-on-Demand (DoD)
  • Sheet Jets

Other sample delivery techniques supplied by user groups (ie. liquid jet, fixed target, goniometer, tape drive, etc.) that are compatible with the basic MFX system could also be considered if the schedule allows it and at the discretion of LCLS.

> For full details of the call, please visit

Questions about the LCLS PCS program should be directed to Christopher Kupitz ( For more general information about LCLS, please visit: