LCLS Call for PCS Proposals for Run 19

By pjones
January 13, 2021

Call for Proposals - Run 19 Protein Crystal Screening
Linac Coherent Light Source - SLAC National Accelerator Laboratory

Deadline: 4:00 p.m. Pacific Daylight Time (PDT) 09 February 2021

We are pleased to announce the next call for LCLS Protein Crystal Screening (PCS) Proposals.

The LCLS Protein Crystal Screening (PCS) program aims to enable increased access to LCLS beamtime for biological structure determination by making use of short, 6-12 hour runs to screen the quality of different sample preparations or potentially collect a full data set under good running conditions. To enable measurements within such a short time frame and maximize efficiency and the chances of success, these studies must be carried out with limited instrumentation flexibility to minimize the time impact of setup changes.

The following configurations are expected to be supported for PCS in this current call for proposals:

  • Gas Dynamic Virtual Nozzle (GDVN)
  • Dual Flow Focusing Nozzles (DFFN)
  • Lipidic Cubic Phase (LCP) jets
  • Microfluidic Electrokinetic Sample Holder (MESH).

Other liquid jet systems supplied by user groups compatible with the basic CXI system could also be considered if the schedule allows it and at the discretion of LCLS. Furthermore, atmospheric pressure measurements using various fixed target or liquid jets systems at MFX are expected to be available. Measurements using other demonstrated atmospheric pressure sample delivery techniques could be considered if the schedule allows it and at the discretion of LCLS. Schedule constraints are unpredictable and no guarantees can be made that any of the mentioned experimental setups will be available for PCS in any given run.

LCLS is seeking proposals for PCS beamtime to be awarded during LCLS Run 19 expected to be scheduled between May 2021 and December 2021. View the latest LCLS long-range operating plans here.

For full details of the call, please visit:

Questions about the LCLS PCS program should be directed to Mark Hunter (

For more general information about LCLS, please visit: