LCLS-PULSE seminar "Mapping the conformations of biological assemblies", Dr. Abbas Ourmazd, University of Wisconsin Milwaukee, October 14, 2009, 4:00-5:00 PM, Bldg 137, Room 322.
The LCLS offer a powerful route to recovering the structure of individual biomolecules from random diffraction snapshots of series of identical molecules. However, biological molecules can assume a variety of conformations. Mapping the conformational heterogeneity of macromolecules presents a formidable challenge to X-ray crystallography, single-molecule coherent diffraction, and cryo-electron microscopy. This has severely limited our knowledge of the conformations assumed by biological systems and their role in biological function, even though they are known to be important. We propose a new approach to determining to high resolution the three-dimensional conformations of biological entities such as molecules, macromolecular assemblies, and ultimately cells, with existing and emerging experimental techniques. This approach may also enable one to circumvent current limits due to radiation damage and solution purification.
For more information, contact Yiping or Haidan LCLS-PULSE seminar organizers.
Yiping Feng
LCLS, Photon Division, X-ray Science Department SLAC National Accelerator Laboratory
2575 Sand Hill Road, Building 280A/Room 288 Menlo Park, CA 94025
(650) 926-2890 - Office
(408) 888-9827 - Cell
(650) 926-3615 - Fax
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